What happens when your IGF-1 is high?

Increased secretion of GH and IGF-1 leads to abnormal glucose regulation, causing diabetes mellitus. A defect in lipid metabolism is also observed in some patients with acromegaly. The high level of IGF-1 in acromegaly is related to an increased risk of some cancers, particularly colon cancer and thyroid cancer.

Does IGF-1 cause water retention?

Conclusion: IGF-I treatment causes fluid and sodium retention. This may be mediated by increased renin release and suppression of atrial natriuretic factor.

How does IGF-1 affect glucose?

Insulin-like growth factor I (IGF-I) has significant structural homology with insulin. IGF-I has been shown to bind to insulin receptors to stimulate glucose transport in fat and muscle, to inhibit hepatic glucose output and to lower blood glucose while simultaneously suppressing insulin secretion.

How do you treat high IGF-1 levels?

The oral medications cabergoline and bromocriptine (Parlodel) may help lower levels of GH and IGF-1 in some people. These drugs may also help decrease tumor size. To treat acromegaly, these medications usually need to be taken at high doses, which can increase the risk of side effects.

How is IGF-1 LR3 different from other growth factors?

IGF-1 LR3 (insulin-like growth factor-1 long arginine 3) is a synthetic, modified construct of insulin-like growth factor-1. Because IGF-1 LR3 does not bind to IGF-1 binding proteins very well, it remains active up to 120 times longer than standard IGF-1. This results in improved half-life for the peptide and thus increased activity.

Are there any side effects to IGF1 LR3 in humans?

IGF1-LR3 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. IGF1-LR3 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption.

What causes low IGF levels in Type 1 diabetics?

Low levels of IGF may be linked to the increased secretion of growth hormones in people with type 1 diabetes. Growth hormone concentrations in people with diabetes are 2 to 3 times higher than in people who don’t have diabetes.

What happens when you take insulin like growth factor ( IGF )?

These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop. If you have diabetes, or even if you don’t, it’s important to check with your doctor before taking supplements that contain any growth hormones.