What can differentiate into plasma cells?

B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. Once released into the blood and lymph, these antibody molecules bind to the target antigen (foreign substance) and initiate its neutralization or destruction.

Do plasma cells express CD45?

In all, 30% of plasma cells expressed CD45 by flow cytometry (median, 14%; range, 0.1–100%).

What happens if you have too many plasma cells?

But with the group of diseases known as plasma cell neoplasms, your body makes too many plasma cells. They make an antibody called “M protein,” which you don’t even need and can cause your blood to thicken. In some plasma cell neoplasms, the cells are cancer and form tumors, usually in your bones.

What is the normal percentage of plasma cells in blood?

Normally, plasma cells make up about 2%–3% of the cells in bone marrow. In people with multiple myeloma, abnormal plasma cells make up at least 10% of the cells in the bone marrow.

What type of cell is a plasma cell?

white blood cell
A plasma cell is a type of white blood cell. Also called plasmacyte.

Are plasma cells CD38 positive?

The neoplastic plasma cells are positive for CD38, CD138 and CD79a. Lambda light chains, CD20 and CD43 are not expressed. There are only scattered CD3 positive T cells.

Where is plasma found in the body?

Blood plasma is a yellowish liquid component of blood that is freed from blood cells, but holds proteins and other constituents of whole blood in suspension. It makes up about 55% of the body’s total blood volume. It is the intravascular part of extracellular fluid (all body fluid outside cells).

What does a plasma cell do?

Plasma cells develop from B lymphocytes (B cells), a type of white blood cell that is made in the bone marrow. Normally, when bacteria or viruses enter the body, some of the B cells will change into plasma cells. The plasma cells make antibodies to fight bacteria and viruses, to stop infection and disease.