What are inflammasome inhibitors?

Inhibitors targeting inflammasome pathways. Inflammasomes are multiprotein platforms that induce a complex signaling cascade resulting in the activation of inflammatory caspases (caspase-1 and caspase 11-4/5).

What is ASC in inflammasome?

Apoptosis-associated speck-like protein containing a CARD (ASC) has a pivotal role in inflammasome assembly and activation. While ASC function has been primarily implicated in innate immune cells, its contribution to lymphocyte biology is unclear.

Does LPS activate the inflammasome?

In humans, caspase-4 is constitutively expressed in many nonmonocytic cells and monocytes; therefore, cytosolic LPS can activate the noncanonical inflammasome without the priming step75.

Is NLRP3 an inflammasome?

The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.

What is meant by inflammasome?

Definition. The inflammasome is a multiprotein intracellular complex that detects pathogenic microorganisms and sterile stressors, and that activates the highly pro-inflammatory cytokines interleukin-1b (IL-1b) and IL-18. Inflammasomes also induce a form of cell death termed pyroptosis.

Is NLRP3 a PRR?

The cytosolic pattern recognition receptor (PRR) NOD-like receptor family, pyrin domain containing 3 (NLRP3) senses a wide range of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).

What triggers Inflammasome?

Inflammasome formation is triggered by a range of substances that emerge during infections, tissue damage or metabolic imbalances. Once the protein complexes have formed, the inflammasomes activate caspase 1, which proteolytically activates the pro-inflammatory cytokines interleukin-1β (IL-1β)3 and IL-18.

Which is the best inhibitor of the NLRP3 inflammasome?

MCC950 is thus a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease.

What kind of endosomal RNA does Eicke Latz have?

Liu K, Sato R, Shibata T, Hiranuma R, Reuter T, Fukui R, Zhang Y, Ichinohe T, Ozawa M, Yoshida N, Latz E, Miyake K. Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages. Int Immunol. 2021 Jun 23. PMID: 34161582.

What kind of probe is Eicke Latz working on?

Keuler T, Gatterdam K, Akbal A, Lovotti M, Marleaux M, Geyer M, Latz E, Gütschow M. Development of Fluorescent and Biotin Probes Targeting NLRP3. Front Chem. 2021; 9:642273.

How does Eicke Latz inhibit HIV 1 replication?

Reif T, Dyckhoff G, Hohenberger R, Kolbe CC, Gruell H, Klein F, Latz E, Stolp B, Fackler OT. Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils.