What is Sapropterin used for?

Sapropterin is used along with a restricted diet to control blood phenylalanine levels in adults and children 1 month of age and older who have phenylketonuria (PKU; an inborn condition in which phenylalanine may build up in the blood and causes decreased intelligence and a decreased ability to focus, remember, and …

Does KUVAN work for classical PKU?

If children with PKU do not follow a Phe-restricted diet, toxic levels of Phe can build up in the brain. KUVAN works with PAH in the body to help reduce Phe levels in the blood. KUVAN assists those with PKU by helping them stay at the target Phe level their doctor recommends.

How does BH4 treat PKU?

The mainstay of treatment in PKU is dietary restriction of phenylalanine (Phe). It has been shown that oral supplementation of tetrahydrobiopterin (BH4) may improve blood Phe control and allow some relaxation of the dietary Phe restriction in responsive individuals with PKU.

How much does it cost to treat PKU?

On average, it costs $15,000 per person per year for treatment of PKU, including $5,000 for medical visits and $10,000 for medical food and formula. The costs of treating an individual with untreated PKU can be up to 13 times the cost of providing proper treatment.

What do you need to know about Kuvan tablets?

KUVAN ® (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution are prescription medicines used to lower blood Phe levels in people with a certain type of Phenylketonuria (PKU). KUVAN is to be used along with a Phe-restricted diet. What is the most important information I should know about KUVAN? Severe allergic reactions.

How is Kuvan used in the treatment of HPA?

Indication. KUVAN ® (sapropterin dihydrochloride) Tablets for Oral Use and Powder for Oral Solution are approved to reduce blood phenylalanine (Phe) levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin- (BH4-) responsive Phenylketonuria (PKU). KUVAN is to be used in conjunction with a Phe-restricted diet.

How is Kuvan used to treat phenylaketonuria?

Phenylketonuria (PKU) is a disorder in which the body cannot break down phenylalanine. Elevated phenylalanine levels can cause problems with thinking and behavior. Kuvan is used to lower blood levels of phenylalanine in people with a certain type of PKU.

What kind of dosing do I need for Kuvan?

KUVAN follows a weight-based dosing regimen that also factors patient age into the equation. KUVAN Tablets can be crushed and administered the same way as KUVAN Powder, or can be swallowed whole See full Instructions for Use for complete information on preparing and taking KUVAN.